SINTESIS SENYAWA ASAM O-(4-METOKSI BENZOIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus)
| ctrlnum |
41384 |
|---|---|
| fullrecord |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://eprints.umm.ac.id/41384/</relation><title>SINTESIS SENYAWA ASAM O-(4-METOKSI BENZOIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA 
MENCIT (Mus musculus)</title><creator>Putri, Astutik</creator><subject>RS Pharmacy and materia medica</subject><description>Background of the study: Synthesis of O- (4-methoxybenzoyl) -5-methylsalicylic acid compound from salicylic acid derivative had been performed. The O- (4-methoxybenzoyl) -5-methylsalicylic acid compound was expected to have higher analgesic activity than aspirin.
Objective of the study: Produce an O- (4-methoxybenzoyl) -5-methalsalicylic acid compound of the reaction between 5-methylsalicylic acid and 4-methoxybenzoyl chloride reactor using an esterification method of acylhalide. 
Method: The synthesis was done using esterification method of acyl halide, while the analgesic activity test using the writhing test method.
Result: New compounds which were produced from the synthesis were crystalline, white, odorless powder with a yield percentage of 34.3% and a melting point of 128.7 - 130.7oC. In TLC test, the results obtained 1 stain using 3 eluents: Ethylacetate: Chloroform (7: 3), Ethylacetate: Ethanol (7: 3), N-hexane: Ethylacetate: Methanol (4:4:2).Structure identification using the UV Spectrophotometer showed that the wavelengths were 206 nm and 258 nm. In the IR spectrophotometer, the wave number showed 3461,64 cm-1 (-OH); 2976,64 cm-1 (CH3); 1738,54; 1685,52 cm-1 (C = O); 1606,57 cm-1 (C = C); 1259.50 cm-1 (COOC). The HNMR spectrometer showed 14 H atoms. The activity test used three doses of 25 mg, 50 mg and 100 mg, each dose using as many as 6 mouse. The percentage of pain barrier were obtained at the dose of 25mg / kgBB = 35,94%, 50mg / kgBB = 54,60%, 100mg / kgBB = 63,78%. O-(O-4-methoxybenzyl) -5-methylsalicylic acid compound had ED50 of 46.54 mg / kgBB while the aspirin compound, which is a salicylic acid derivative, had ED50 of 135.68 mg / kgBB.
Conclusion : The acid compounds of O-(4-methoxybenzoyl)- 5-methyl salicylate was successfully synthesized and had a higher activity than aspirin.</description><date>2018</date><type>Thesis:Thesis</type><type>PeerReview:NonPeerReviewed</type><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/1/Pendahuluan.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/2/BAB%20I.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/3/BAB%20II.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/4/BAB%20III.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/5/BAB%20IV.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/6/BAB%20V.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/7/BAB%20VI.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/8/BAB%20VII.pdf</identifier><type>Book:Book</type><language>eng</language><identifier>http://eprints.umm.ac.id/41384/9/Lampiran.pdf</identifier><identifier> Putri, Astutik (2018) SINTESIS SENYAWA ASAM O-(4-METOKSI BENZOIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus). Bachelors Degree (S1) thesis, University of Muhammadiyah Malang. </identifier><recordID>41384</recordID></dc>
|
| language |
eng |
| format |
Thesis:Thesis Thesis PeerReview:NonPeerReviewed PeerReview Book:Book Book |
| author |
Putri, Astutik |
| title |
SINTESIS SENYAWA ASAM O-(4-METOKSI BENZOIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA
MENCIT (Mus musculus) |
| publishDate |
2018 |
| topic |
RS Pharmacy and materia medica |
| url |
http://eprints.umm.ac.id/41384/1/Pendahuluan.pdf http://eprints.umm.ac.id/41384/2/BAB%20I.pdf http://eprints.umm.ac.id/41384/3/BAB%20II.pdf http://eprints.umm.ac.id/41384/4/BAB%20III.pdf http://eprints.umm.ac.id/41384/5/BAB%20IV.pdf http://eprints.umm.ac.id/41384/6/BAB%20V.pdf http://eprints.umm.ac.id/41384/7/BAB%20VI.pdf http://eprints.umm.ac.id/41384/8/BAB%20VII.pdf http://eprints.umm.ac.id/41384/9/Lampiran.pdf http://eprints.umm.ac.id/41384/ |
| contents |
Background of the study: Synthesis of O- (4-methoxybenzoyl) -5-methylsalicylic acid compound from salicylic acid derivative had been performed. The O- (4-methoxybenzoyl) -5-methylsalicylic acid compound was expected to have higher analgesic activity than aspirin.
Objective of the study: Produce an O- (4-methoxybenzoyl) -5-methalsalicylic acid compound of the reaction between 5-methylsalicylic acid and 4-methoxybenzoyl chloride reactor using an esterification method of acylhalide.
Method: The synthesis was done using esterification method of acyl halide, while the analgesic activity test using the writhing test method.
Result: New compounds which were produced from the synthesis were crystalline, white, odorless powder with a yield percentage of 34.3% and a melting point of 128.7 - 130.7oC. In TLC test, the results obtained 1 stain using 3 eluents: Ethylacetate: Chloroform (7: 3), Ethylacetate: Ethanol (7: 3), N-hexane: Ethylacetate: Methanol (4:4:2).Structure identification using the UV Spectrophotometer showed that the wavelengths were 206 nm and 258 nm. In the IR spectrophotometer, the wave number showed 3461,64 cm-1 (-OH); 2976,64 cm-1 (CH3); 1738,54; 1685,52 cm-1 (C = O); 1606,57 cm-1 (C = C); 1259.50 cm-1 (COOC). The HNMR spectrometer showed 14 H atoms. The activity test used three doses of 25 mg, 50 mg and 100 mg, each dose using as many as 6 mouse. The percentage of pain barrier were obtained at the dose of 25mg / kgBB = 35,94%, 50mg / kgBB = 54,60%, 100mg / kgBB = 63,78%. O-(O-4-methoxybenzyl) -5-methylsalicylic acid compound had ED50 of 46.54 mg / kgBB while the aspirin compound, which is a salicylic acid derivative, had ED50 of 135.68 mg / kgBB.
Conclusion : The acid compounds of O-(4-methoxybenzoyl)- 5-methyl salicylate was successfully synthesized and had a higher activity than aspirin. |
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IOS4109.41384 |
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Universitas Muhammadiyah Malang |
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136 |
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library:university library |
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Perpustakaan Universitas Muhammadiyah Malang |
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546 |
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UMM Institutional Repository |
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4109 |
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MALANG |
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JAWA TIMUR |
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IOS4109 |
| first_indexed |
2019-05-07T01:46:22Z |
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2019-05-07T01:46:22Z |
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dc |
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1675924491338776576 |
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17.538404 |