PENGARUH EKSTRAK KULIT KENTANG(Solanum tuberosum L. ) TERHADAP KADAR MALONDIALDEHID (MDA) HATI TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar) MODEL STEATOSIS
Daftar Isi:
- Backgrounds:Steatosis could develop into dangerous diseases such as liver cirrhosis and hepatoma, characterized by elevated levels of liver MDA. One of the causes of steatosis was oxidative stress. Steatosis could be inhibited by consuming potato peel extract (Solanum tuberosum L) containing antioxidant compounds as a preventative oxidative stress. Objectives: determining the effect of potato peel extract on MDA leve in liver of white male rat at steatosis model. Methods:True experimental with post test only control group design, divided into 5 groups. All groups were fed standard food BR-1. Negative control group only has standard food without any treatment, positive control group and treatment groups were given CCl4 injection. Treatment groups were given potato peel extract(200,400,800mg/200grBB/day). Data was analyzed using normality test, one way anova, post-hoc benferoni test and linier regression test. Results and Discussion:Potato peel extracts significantly decreased liver MDA levels, with best results showed in the P3 group (dose 800mg / 200grBB) of 0.53 nmol / ml. One wayanova test showed significant influence (p <0,05). Post Hoc test results showed significant differences in all treatment groups. The result of linear regression test obtained R2 = 0,783. Increased levels of MDA inhibited by antioxidants contained in potato peel extract by inhibiting the occurrence of oxidative stress Conclusion: decreasing amount of MDA was found onsteatosis model male white rat that was given potato peel extract.