UJI AKTIVITAS SENYAWA DALAM TANAMAN BERPOTENSI SEBAGAI OBAT BATUK DENGAN METODE IN SILICO (Pada tanaman Glycyrhiza glabra Radix dan Zingiber officinale Rhizoma)
Daftar Isi:
- Background: Cough is a reflex which occurs in a sudden thatrepeated frequently in order to clear the respiratory tract of mucus, irritants, foreign particles, and microbes. In this study, docking of metabolite compounds in plants that have been tested using in vitro which potentially to be a cough medicine, namely in Zingiberis rhizoma and Glycyrrhiza radix, using antitussive class of receptors (2WAL), antihistamines (2AOT) and bronchodilators (2Y03). However, in a pre-existing study, there has been no molecular explanation regarding the mechanism of its action in metabolite compounds that have the activity as a cough medicine. Therefore, it developed again by doing research in silico. Objective: To identify which metabolite compound of Zingiberis rhizoma and Glycyrrhiza radix that can give the activity as cough medicine and to predict the mechanism of action in the plant metabolite compound in silico. Method: This study used Autodock Vina and Discovery Studio application. Result and conclusion: According to the results analysis, it can be concluded that 42 metabolite compounds in Zingiberis rhizoma that have been tested, it is predictedaround 26 compounds have antitussive activity, 6 compounds have antihistamine activity, and 16 compounds have bronchodilator activity, whereas 113 metabolite compounds in Glycyrrhiza radix which have been tested, it is suspected 38 compounds have antitussive activity, 13 compounds have antihistamine activity, and 25 compounds have bronchodilator activity.