PENGARUH EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) TERHADAP JUMLAH HEPATOCYTE SWELLING TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar) YANG DIINDUKSI ALKOHOL
Daftar Isi:
- Background : Alcohol is one of the chemical substance that is in charge of hepatocyte destruction, which can be seen by the amount of hepatocyte swelling. Noni fruit extract contains proxeronine, vitamin A, ascorbic acid, riboflavin and scopoletin that works as antioxidant. Objective: determining the effect of Noni fruit (Morinda citrifolia L.) extract towards the amount of hepatocyte swelling in alcohol-induced male white rat. Methods: true experimental with post test only control group design. Sample was divided into 4 groups, all of them were given 2 ml/200grBW of alcohol, while group 1, 2 and 3 were given Noni fruit extract of 22.4, 44.8 and 89.6 (ml/200grBW) respectively for 28 days. Data was analyzed using Kruskal-Wallis, Post Hoc Mann-Whitney test and linear regression test. Results: Kruskal-Wallis resulted in signification of 0.001, implying the existence of the effect of Noni fruit extract towards the reduction of hepatocyte swelling (p<0.05). Post-Hoc test showed that there were significant difference (p<0.05) between control group and treatment group 2 and 3. Linier regression test resulted in R2=0,818 which showed that Noni fruit extract (Morinda citrifolia L.) had 81.8% influence towards the reduction of hepatocyte swelling because of its contents: proxeronine, vitamin A, ascorbic acid, riboflavin and scopoletin. Conclusion: Noni fruit extract administration could suppress the amount of hepatocyte swelling in alcohol-induced male white rat.