The Effect of Administration of Leveled Dose Omega-3 Fatty Acid as an Antiinflamatory to the Kidney Histopathological Change of Formalin-Induced White Male Rats (Rattus norvegicus strain wistar)
Daftar Isi:
- Background: The usage of formalin as food preservative caused negative effect to the body part such as kidney. One of the effects is the damage of kidney’s cell that can cause tubule necrosis or well-known as Acute Tubular Necrosis (ATN). Purpose: Proving the effect of omega-3 to the histopathological image on the kidney of formalin-induced white male rats. Method: Experimental study with The Post Test Only Control Group Design. This experiment used 5 groups and each group consisted of 5 rats (negative control, positive control, fatty acid omega-3 dose 200mg/KgBW/day, 400mg/KgBW/day, 800mg/KgBW/day). After 14-days The kidneys were taken then being analyzed to know the average amount of thyroidisation of tubule. Result: 1% Tukey test showed that the administration of dose 800mg/KgBW/day yielded a similar result with negative control. The administration of fatty acid omega-3 strongly affected in a negative way, the decrease of the average amount of thyroidisation of kidney’s tubule (R= -0,880). Conclusion: It is proven that fatty acid omega-3 has anti inflammatory activity that can prevent the damage of kidney’s cell on formalin induced white male rats.