MODIFIKASI STRUKTUR SALISILAMIDA MENJADI N-HEKSANOIL SALISILAMIDA
| Main Author: | YULIANTI, FIRDHA ANITA |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2013
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| Subjects: | |
| Online Access: |
http://eprints.umm.ac.id/28351/1/jiptummpp-gdl-firdhaanit-33592-1-pendahul-n.pdf http://eprints.umm.ac.id/28351/2/jiptummpp-gdl-firdhaanit-33592-2-babi.pdf http://eprints.umm.ac.id/28351/ |
Daftar Isi:
- Salicylamide is one of NSAID class that have weak therapeutic effect of analgesic and antipyretic. Therefore, a novel Salicylamide derivative was synthesized by modified Schotten-BaumannÂ’s method on asilation reaction. Reaction between Salicylamide and Hexanoyl chloride for 2 hours to produce N-Hexanoyl Salicylamide. Target compound purified by recrystalisation. The purity was identified using Thin Layer Chromatography (TLC) & melting point test. The yield percentage of target compound was 0,68%. Purified compound characterized and identified by spectrometer 1HNMR, spectrofotometer FTIR KBr and UV. Product compound form white crystal with melting range about 134-135oC. Spectra of 1HNMR and FTIR KBr showed that pure N-Hexanoyl Salicylamide was successfully synthesized. Keyword: Salicylamide, N-Heksanoyl Salicylamide, Schotten-Baumann