UJI EFEKTIVITAS EKSTRAK BIJI JINTAN HITAM (NIGELLA SATIVA) TOPIKAL SEBAGAI ANTI DRY EYE SYNDROME (DES) PADA KELINCI JANTAN LOKAL PERANAKAN NEW ZEALAND WHITE (NZW) YANG DIINDUKSI KAPORIT (NaOCl) (UJI SCHIRMER)
| Main Author: | WIRAWAN, BAGUS PRASETYA |
|---|---|
| Format: | Thesis NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2016
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| Subjects: | |
| Online Access: |
http://eprints.umm.ac.id/23289/1/jiptummpp-gdl-bagusprase-42357-1-pendahul-n.pdf http://eprints.umm.ac.id/23289/2/jiptummpp-gdl-bagusprase-42357-2-bab1.pdf http://eprints.umm.ac.id/23289/ |
Daftar Isi:
- Advisor : (1) Alfa Sylvestris (2) Maryam Abdullah. Background : Mild or acute inflammation is an early and quick response on cellular damage which characterized by redness, swelling, heat, pain, and loss of function. These processes underlie the early onset of dry eye-related ocular surface disorder. It has been approved that blackseed (Nigella sativa) has the ability to decrease mediators of inflammation and degree of dry eye disease symptoms. Aim of The Study :To understand the effectivity of blackseed (Nigella sativa) topical extract as anti Dry Eye Syndrome (DES) in local male New Zealand White (NZW) crossbreed rabbit induced chlorine (NaOCl) with Schirmer test. Method of Study :This experiment used true experimental design with pre test and post test only control and simple random sampling. As the result, 24 samples of rabbit were obtained and divided into 4 groups. Each group consist of 6 samples then being treated for 7 days. Result :Anova test showed that there were significant difference by 0,000 (p<0,05). Pearson correlation test by 0,000 (p<0,05) with the direction of positive correlation and the strength of correlation at 84,5%. The equation of regression test was Y = 3,550 + 9,278 X. And from T paired test could be concluded that the maximum concentration of blackseed (Nigella sativa) topical extract was 0,7% (p<0,05). Conclusion : There was significant effect of the blackseed(Nigella sativa) topical extract in increasing Schirmer test result in rabbit.