BIOTRANSFORMATION OF CINCHONA ALKALOID COMPOUNDS BY MOLD Xylaria sp.TO CINCHONA N-OXIDE ALKALOIDS [Studies on Endophytic Microbes of Cinchona spp. plants (5)]
| Main Authors: | Simanjuntak, Partomuan; Biotechnology Center Science Institute of Indonesia Jalan Raya Bogor Km 46 Cibinong 16911, ., Bustanussalam; Biotechnology Center Science Institute of Indonesia Jalan Raya Bogor Km 46 Cibinong 16911, Prana, Titik K.; Biotechnology Center Science Institute of Indonesia Jalan Raya Bogor Km 46 Cibinong 16911, Ohashi, K.; Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan, Shibuya, Hirotaka; Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan |
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| Format: | Article info Journal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2005
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/713 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/713/574 |
Daftar Isi:
- A biotransformation study on alkaloid chinchona compounds (quinine, quinidine, cinchonidine, cinhonine) by endophytic microbe from Cinchona succirubra have been done. The biotransformation for 2 days after preculture yielded cinchona N-oxide compounds (quinine N-oxide, quinidine N-oxide, cinchonidine N-oxide, cinchonine N-oxide) alkaloids and the bioassay of the compounds also showed effectiveness as antimalaria. Purification the biotransfomed compound was conducted by a high performance liquid chromatograph (HPLC) and determination of chemical structure was done based on carbon nuclear magnetic resonance (NMR).Key words : Biotransformation, endophyte microbe, Xylaria sp., Cinchona succirubra Pav., cinchona alkaloid, quinine, quinine N-oxide