Identification of physical interaction between levodopa–benzerazide hydrochloride
| Main Authors: | Nugrahani, Ilma; School of Pharmacy Institut Teknologi Bandung, Jl Ganesha 10, Bandung 40132 Phone : 08129027310, 022-2504852/022-2504852, Asyarie, Sukmadjaja; School of Pharmacy Institut Teknologi Bandung, Soewandhi, Sundani Noerono; School of Pharmacy Institut Teknologi Bandung, Ibrahim, Slamet; School of Pharmacy Institut Teknologi Bandung |
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| Format: | Article info Journal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2007
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/449 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/449/328 |
Daftar Isi:
- The aim of this research was to investigate the possibility physical interaction occurred between of levodopa and benzerazide hydrochloride, which known as compounds used in combination for the the antiparkinson. The “cold contact methods” was used which was developed from Kofler contact method’s (hot stage methods). Thermograms Differential Scanning Calorimetry and difractograms X-Ray indicated that levodopa – benzerazide hydrochloride tent to form a peritecticum-molecular compound physical interaction with eutectics point at 4:6 and 9:1 molar ratios.Key words: benzerazide hydrochloride, cold contact method, levodopa, physical interaction.