Phalerin, a new benzophenoic glucoside isolated from the methanolic extract of Mahkota Dewa [Phaleria macrocarpa (scheff). Boerl.] leaves
| Main Authors: | Hartati W, Mae Sri; Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia, Mubarika, Sofia; Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia, Gandjar, Ibnu G; Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia, Hamann, Mark T; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, USA, Rao, KV; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, USA, Wahyuono, Subagus; Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia |
|---|---|
| Format: | Article info Journal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2005
|
| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/336 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/336/217 |
Daftar Isi:
- Mahkota Dewa [Phaleria macrocarpa (Scheff). Boerl.] is used traditionally to treat cancers in Indonesia. Extract methanol of the leaves displayed a small LC50 value (63.16 μg/ml) on BST (Brine Shrimp Lethality test) assay; therefore a phytochemical study of this extract was undertaken. A new benzophenoic glucoside was isolated from the methanol extract and identified as 4,5-dihydroxy,4’-methoxybenzophenone-3-0-β-D-glucoside (Phalerin) based on its spectroscopic data. Phalerin was cytotoxic to myeloma cell line (NS-1) (in vitro) having IC50 of 83 μg/ml or 1.9 x 10-1 mM.Key words: Phaleria macrocarpa, Phalerin, myeloma