FORMULA OPTIMIZATION OF LOZENGES CONTAINING Alpinia galanga (L.) Stuntz RHIZOME EXTRACT WITH A COMBINATION OF MANNITOL AND SUCROSE SWEETENERS USING SIMPLEX LATTICE DESIGN METHOD
| Main Authors: | Aufiya, Duhita, Pramono, Suwijiyo, Mufrod, Mufrod |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | ind |
| Terbitan: |
Faculty of Pharmacy, Universitas Gadjah Mada
, 2015
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| Subjects: | |
| Online Access: |
https://jurnal.ugm.ac.id/TradMedJ/article/view/8009 https://jurnal.ugm.ac.id/TradMedJ/article/view/8009/6218 |
Daftar Isi:
- Galangal (Alpinia galanga (L.) Stuntz) has many benefits for the health. Galangal is used as a tonic traditionally, but the dose is unknown, so it is necessary to be formulated. Lozenges was selected for the formulation of galangal because its practical and comfortable form. Taste is an important parameter for the lozenges so a mixture of mannitol and sucrose are used in this formulation. This research aims to optimize the lozenges formulation using a mixture of mannitol and sucrose with Simplex Lattice Design method. Galangal rhizome was extracted by maceration using 70% ethanol. Lozenges were made in three formulas, Formula A (100%: 0%), Formula B (50%: 50%), and Formula C (0%: 100%) with SLD in wet granulation method. Granule mass was sieved through the sieve no. 10 and dried in an oven at 60°C, then dried granule was mixed homogeneously with magnesium stearate-talk and tested for its physical properties include flow rate and compactibility. The granule was compressed into tablets and tested for its physical properties, including weight uniformity, hardness, friability, dissolving time, and tasting test. The data which was obtained were used to create a profile of physical properties of the granule and the taste of the tablet. Optimum formula was selected based on the highest total response. The tablet was created based on the optimum formula and tested physical properties of granule and tablets. The data was obtained and compared theoritically and statistically using the T-Test. The result showed that optimum formula of galangal rhizome extract lozenges is a formula with ratio 25% maintol : 75% sucrose. The optimum formula of the flow rate and granule compactibility and significantly different between verification and SLD calculations, while the dissolved time and the respon of tablets flavor are not significantly different. The dominant composition of sucrose can increase granule's compactibility response, dissolving time, and tasting test of lozenges, lowering the response speed of the flow of granules.
- Lengkuas (Alpinia galanga (L.) Stuntz) memiliki banyak manfaat bagi kesehatan tubuh, diantaranya sebagai tonikum. Lengkuas sebagai tonikum masih digunakan secara tradisional, sehingga dosis tidak tetap dan tidak praktis, maka perlu dilakukan formulasi. Tablet hisap dipilih untuk formulasi lengkuas karena praktis dan nyaman. Rasa merupakan parameter yang penting untuk tablet hisap. Oleh karena itu digunakan campuran antara manitol dan sukrosa. Penelitian ini bertujuan untuk optimasi formula tablet hisap menggunakan campuran manitol dan sukrosa dengan metode Simplex Lattice Design. Ekstrak rimpang lengkuas diperoleh dengan maserasi menggunakan etanol 70%. Tablet hisap dibuat dalam tiga formula yaitu Formula A (100%:0%), Formula B (50%:50%), dan Formula C (0%:100%) dengan metode SLD secara granulasi basah. Massa granul diayak melalui pengayak no. 10 dan dikeringkan dalam oven suhu 60°C, kemudian granul kering dicampur homogen dengan Mg stearat-talk, selanjutnya diuji sifat fisik meliputi kecepatan alir dan kompaktibilitas. Granul dikempa menjadi tablet dan diuji sifat fisik, meliputi keseragaman bobot, kekerasan, kerapuhan, waktu larut, serta tanggap rasa. Data yang diperoleh digunakan untuk membuat profil sifat fisik granul dan rasa dari tablet. Formula optimum dipilih berdasarkan respon total tertinggi. Kemudian dibuat tablet berdasarkan formula optimum dan diuji sifat fisik granul dan tablet. Data yang diperoleh kemudian dibandingkan secara teoritik dan statistik menggunakan T-test. Hasil yang diperoleh menunjukkan bahwa formula optimum tablet hisap ekstrak rimpang lengkuas adalah formula dengan perbandingan 25% manitol : 75% sukrosa. Kecepatan alir dan kompaktibilitas granul formula optimum berbeda bermakna antara verifikasi dengan perhitungan SLD, sedangkan waktu larut dan tanggap rasa tablet berbeda tidak bermakna. Komposisi sukrosa yang dominan dapat menaikkan respon kompaktibilitas granul, waktu larut, dan tanggap rasa tablet hisap, menurunkan respon kecepatan alir granul.