The Role of Leptin Toward the Activity of Maturation-Promoting Factor (MPF) at Oocyte Maturation
| Format: | Book |
|---|---|
| Terbitan: |
Puslitbang Farmasi, Badan Litbang Kesehatan
, 2008
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| Subjects: | |
| Online Access: |
http://perpustakaan.litbang.depkes.go.id/ucs/index.php?p=show_detail&id=77 |
Daftar Isi:
- Oocyte maturation is mediated by active Maturation Promoting Factor (MPF)in ooplasma. Maturation Promoting Factor (MPF) is heterodimer protein consists of sub catalytic unitp34cdc2 and sub regulator unit of cyclin-B . The regulation of maturation promoting factor (MPF) occurs throught phosphorylation and dephosphorilation Cdc2 while its acitivities are controlled by the accumulation and periodical degradation from Cyclin-B during cell cycles development. Leptin in known has role on oocyte maturation that works at mitogen activated protein kinase (MAPK). MAPK belongs to protein kinase family Ser/Thr that interact with MPF in arranging the proresivennas of oocyte meiosis through the help of c-mos. This interactions initiated phosphorilation of Ser-369 and Thr-577 in p90rsk.
- 5P.