Evaluasi Kualitatif Antibiotik Meropenem pada Pasien Sepsis BPJS di RUMKITAL Dr. Mintohardjo
| Main Author: | Athirotin Halawiyah |
|---|---|
| Other Authors: | Azrifitria, Yardi |
| Format: | Bachelors |
| Bahasa: | in |
| Subjects: | |
| Online Access: |
http://repository.uinjkt.ac.id/dspace/handle/123456789/29078 |
Daftar Isi:
- Sepsis is a systemic and deleterious body response to infection. Sepsispatientsrequire abroad-spectrumantibiotictherapywhen thepathogenic bacteria that infects the bodyis unknown. Meropenem is a broad spectrum antibiotic that has a high potential as an empirical and definitive therapy against serious infections caused by multi-drug resistant organism (MDRO) The antibiotic resistance may emerge as a result of inappropriate use of antibiotic. This study aimed to evaluate the quality (appropriateness) use of meropenem in Naval Hospital Dr. Mintohardjo using Gyssens’ flowchart. Certain parameters have been analyzed, which are the adequacy of the data, indication, antibiotic choice, duration, dosage, interval, route and timing of antibiotic usage.This is retrospective study using descriptive-case study approach. Data for this study were drawn from patient’s medical records from January-December 2014 periode. The data retrieval was done by using the total sampling technique, where 26 samples were obtained in accordance with the study inclusion criteria. Patient characteristics were observed, showed that the most common sepsis type is nosocomial sepsis (42%), disease comorbidity is cerebrovascular sepsis (29%), the mean duration of treatment is 20 days, the number of drug received are 13 and the number of antibiotic received is 3. Meropenem was given as empirical therapy in 24 patients (92,3%) and definitive therapy in 2 patients (7.7%). The result of the qualitative evaluation of meropenem use showed that 15% were appropriate (category 0), and 85% were inappropriate (category I-VI). The inappropriate use of meropenem, 9% due to inappropriate dose, 24 % innapropriate interval, 6% duration too long, 49% because there were alternatives that more effective, 3% alternatives that have narrower spectrum, and 9% data insufficiency. Referring to this result, the use of antibiotic meropenemin patients with sepsis in RUMKITAL Dr.Mintohardjo requires efforts in improving the quality of use and prevention of meropenem resistance. Key word: Antibiotic evaluation, Gyssens category, meropenem, sepsis