Validity of Eosinopenia as a Diagnostic Marker of Neonatal Bacterial Sepsis
| Main Authors: | Yefta, Emanuella Kurniati; School of Medicine Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Yuniati, Tetty; School of Medicine Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Rahayuningsih, Sri Endah; School of Medicine Padjadjaran University, Hasan Sadikin General Hospital, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2009
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/895 |
Daftar Isi:
- Diagnosis of neonatal sepsis is still a major problem. Eosinophil is a forgotten marker of acute infection. The reduction in the number of circulating eosinophils was assumed as a secondary response to stress caused by acute bacterial infection. The aim of the present study is to assess validity of eosinopenia as a diagnostic marker in neonatal bacterial sepsis. A crosssectional study was performed on all neonates aged <28 day old in Child Health Department Hasan Sadikin General Hospital Bandung between June and July 2009. Blood samples were obtained for eosinophil count and blood culture at the time patient was suspected sepsis. Statistical analysis was done by the Pearson chi-square and Mann-Whitney tests. Receiver operating characteristic (ROC) curve was used to determine the cut-off value of eosinophil count. A total of 91 patients were enrolled, 56 neonates were classified as sepsis group and 35 neonates as nonsepsis group. Sepsis group had a mean percentage of eosinophil of 1.16% versus 1.65% in nonsepsis group; it showed significant difference (Mann Whitney test, p=0.005). Eosinophil at <0,78% yielded a sensitivity of 69.6% (95% CI, 55.9-81.2%), a specificity of 74.3% (95% CI, 56.7-87.5%), and accuracy of 71.4%. Eosinopenia is a diagnostic marker of neonatal bacterial sepsis.Keywords: Neonatal, sepsis, eosinophil