Differences of Serum Ferritin Levels in Children with Thalassemia Major after Deferiprone and Deferoxamine Iron Kelator Administration
| Main Authors: | Ismail, Yulia; Faculty of Medicine Padjadjaran University/ Dr. Hasan Sadikin Hospital, Bandung, Reniarti, Lelani; Faculty of Medicine Padjadjaran University/ Dr. Hasan Sadikin Hospital, Bandung, Hilmanto, Dany; Faculty of Medicine Padjadjaran University/ Dr. Hasan Sadikin Hospital, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2010
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/751 |
Daftar Isi:
- Routine serum ferritin examination was used to evaluate response of iron chelator in thalassemia major. Iron chelator which was widely used were deferoxamne (DFO) and deferiprone (DFP). Iron loading in thalassemia major patients continued despite iron chelation therapy, so effective and continue iron chelator agent was needed. This study was aimed to know the difference of ferritin serum levels after DFO and DFP therapy in 6, 12, and 18 months. A cross sectional study was performed between May and August 2009 in Hasan Sadikin General Hospital Bandung. Forty eight children with thalassemia major were analyzed. There were statistical differences between DFO or DFP administration (Factor-A) with serum ferritin level (p=0.002) and between 6, 12, 18 months administration time (Factor-B) with serum ferritin level (p<0.001). Interaction between both factors was not significantly different (p=0.645). In conclusion, type and administration time of iron chelator effect in serum ferritin level.Keywords: deferiprone, deferoxamine, ferritin, thalassemia major