Correlation Between Serum Feritin Level with Delayed Puberty in Thalassemia Major Children
| Main Authors: | Anggororini, Deby; Facuty of Medicine Padjadjaran University/ Dr. Hasan Sadikin Hospital, Bandung, Fadlyana, Eddy; Facuty of Medicine Padjadjaran University/ Dr. Hasan Sadikin Hospital, Bandung, Idjradinata, Ponpon; Facuty of Medicine Padjadjaran University/ Dr. Hasan Sadikin Hospital, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2010
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/745 |
Daftar Isi:
- One factor that interferes with optimal growth and development is thalassemia mayor, which requires regular repeated transfusion. The aim of this study was to determine the correlation between feritin serum level with delayed puberty in thalassemia major children. An observational study with case-control design was conducted at Thalasemia Clinic of Hasan Sadikin Hospital Bandung. The subjects of this study were patients with thalassemia major aged 10-18 years visiting the clinic on March to April 2009. Diagnosis of thalassemia was established from medical record. We performed sexual maturity examination using Tanner scala. Feritin serum and sex hormone measurement were analyzed with ECLIA method. Subjects consisted of 30 patients with thalassemia major. Control group were 30 healthy children with same characteristics. Most of thalassemia subjects had delayed puberty (83%). All control group had normal sexual maturity (p<0.001). A group with delayed puberty had higher serum feritin level than normal sexual maturity group. There was correlation between serum feritin level with delayed puberty in patient with thalassemia major (rs= 0.435, p= 0.018). More intervention is needed to prevent high serum feritin level.Keywords: serum feritin level, delayed puberty, thalassemia major