The Relationship of Angiotensin-Converting Enzyme Gene Polymorphism Insertion/Deletion and Hypertension in Yogyakarta Population, Indonesia
| Main Authors: | Aziza, Lucky; Faculty of Medicine University of Indonesia, Jakarta, Sja’bani, Mochammad; Faculty of Medicine University of Gadjah Mada, Yogyakarta, Haryana, Sofia Mubarika; Faculty of Medicine University of Gadjah Mada, Yogyakarta, Soesatyo, Marsetyawan HNE; Faculty of Medicine University of Gadjah Mada, Yogyakarta, Sadewa, Ahmad Hamim; Faculty of Medicine University of Gadjah Mada, Yogyakarta |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2010
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/717 |
Daftar Isi:
- Hypertension is one of major health problem in the world. It becomes complicated since the blood pressure (BP) still uncontrollable, including in Yogyakarta, Indonesia. The reninangiotensin system (RAS) has a central role in controlling BP and sodium homeostasis. RAS polymorphism was defined as genetic determinants of essential hypertension and end-organ damage. One of enzyme that work in RAS, which have a role on hypertension pathogenesis is angiotensin converting enzyme (ACE). ACE convert angiotensin I to angiotensin II. The act of ACE is influenced by ACE gene. In the world, there are many study about the role of ACE gene polymorphism I/D to hypertension. That studies show controversial result. The objective of this study is to evaluate the association between ACE gene polymorphism I/D and hypertension in Yogyakarta population. The method of this study is cross sectional. Sample was taken by double random sampling method from hypertension, prehypertension and normotension, was obtained 125 subjects, 97 subjects dan 108 subjects, consecutively. ACE gene polymorphism I/D was examined by PCR. This study shows significant differences of three groups (ages, body mass index (BMI), and family history of hypertension) and total cholesterol level in blood, which is tend to have greater value in the hypertension group. Frequency of genotype II, ID, DD are 85 (68%), 39(31.2%), 1(0.8%) in hypertension, 66 (61.1%), 38(35.2%), 4(3.7%) in normo-tension and 56(57.7%), 37 (38.1%), 4 (4.1%) in pre-hypertension subject, consecutively. The result of Chi- Square analysis shows statistically significant association between ID+DD vs. II genotype and hypertension. Multiple logistic regression analysis shows four variables that significantly influent to hypertension, namely ages, family history of hypertension, BMI, and ACE gene polymorphism. The conclusion of this study is ACE ID+DD genotype has significant relationship with hypertension in Mlati population, Sleman, Yogyakarta, Indonesia.Keywords: hypertension, genetic, ACE, polymorphism, insertion/deletion