Inflammation, Immunity, and Cancer: The Role of Transcription Factors NF-kB and STAT3
| Main Authors: | Khiong, Khie; Faculty of Medicine, Maranatha Christian University, Bandung, Adhika, Oeij Anindita; Faculty of Medicine, Maranatha Christian University, Bandung, Chakravitha, Melisa; Faculty of Medicine, Maranatha Christian University, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2010
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/676 |
Daftar Isi:
- A link between inflammation and cancer has long been suspected. Recent studies have identified the role of transcription factors nuclear factor-kB (NF-kB) and signal transducer and activator of transcription 3 (STAT3) in inflammation-induced tumor. In this review, we focus on the role of NF-kB and STAT3 in regulating functions of cancer cells and surrounding nontumorigenic cells to create a tumor microenvironment that enhance tumor promotion and progression.Key word: inflammation, cancer, NF-kB, STAT3