Association of Hemoglobin Level Before Transfusion and Iron Chelating Agents with Growth Velocity in Childhood Thalassemia Major
| Main Authors: | Ermaya, Yudith Setiati; Faculty of Medicine Padjadjaran University / Hasan Sadikin Hospital, Bandung, Hilmanto, Dany; Faculty of Medicine Padjadjaran University / Hasan Sadikin Hospital, Bandung, Reniarti, Lelani; Faculty of Medicine-Padjadjaran University / Hasan Sadikin Hospital, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2007
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/547 |
Daftar Isi:
- The association between thalassemia major and growth retardation has been known, but the factors affect growth velocity remain unclear. The aim of this study was to determine mean hemoglobin level before transfusion and iron chelating agents as risk factors for growth velocity retardation in childhood thalassemia major. The study was conducted from October 2006 to April 2007 at the Clinic of Pediatric Thalassemia Hasan Sadikin Hospital Bandung. The subjects meeting inclusion criteria were examined for the average hemoglobin level (g/dL) and optimalization of iron chelating agents. Afterwards, we performed growth velocity calculation (cm/year). Association of hemoglobin level before transfusion and iron chelating agents with growth velocity were analyzed by odds rasio (OR). Fifty-five subjects of 30 male and 25 female, with ages ranged from 4 years 1 month to 9 years 10 months. Fourteen subjects received transfusion when hemoglobin level was <7 g/dL, and 41 subjects e”7 g/dL. The average iron chelating agents administered was (45±4.95 mg/kgBW); forty-six subjects received inoptimal iron chelating agents and nine subjects optimal. Forty-two subjects had growth velocity retardation (<4.5 cm/year) and 13 subjects had normal growth (e”4.5 cm/year). The association of mean hemoglobin level before transfusion and optimalization iron chelating agents with growth velocity were, respectively, (OR=5.6; p=0.117) and (OR=0.7; p=0.727). It was concluded that mean hemoglobin level before transfusion and iron chelating agents are not significant risk factors for growth velocity retardation in chilhhood thalassemia major.Keywords: Thalassemia major, mean hemoglobin level, growth velocity, risk factor