Red Fruit as Antioxidant for Treatment of Malaria Berghei in Balb/C Strain Mice
| Main Authors: | Tjahjani, Susy; Faculty of Medicine Maranatha Christian University, Bandung, Khiong, Khie; Faculty of Medicine, Maranatha Christian University, Bandung |
|---|---|
| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2010
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/523 |
Daftar Isi:
- Morbidity and mortality of malaria in Indonesia are still high due to anti-malaria drug resistance and free radicals. Proinflammatory cytokines such as TNF-a play important role in the pathogenesis of malaria while ICAM-1 plays a key role in cerebral malaria, one of malaria’s complications. Various studies have been done to search alternative treatments for the disease. One of them is red fruit (Pandanus conoideus Lam.) which contains high level of antioxidants. The aims of this study were to investigate the effect of buah merah as antioxidant by decreasing the degree of parasitemia, TNF-a and ICAM-1 serum levels in Plasmodium berghei-inoculated mice. This was an experimental study, with complete randomized design. Thirty male Balb/C mice were divided into six groups: negative control group, red fruit control group, Plasmodium control group, buah merah 0.1 mL, 0.2 mL and 0.4 mL group. TNF-a and ICAM-1 serum levels were measured using ELISA method and all data were analyzed by One Way ANOVA and Post Hoc Tukey-HSD. The result showed, the degree of parasitemia reduced significantly in buah merah treated mice (0.2 mL) compared to Plasmodium control (p=0.000) whereas TNF-a and ICAM-1level were significantly different between red fruit 0.2 ml and Plasmodium control group (p=0.02 and 0.001 respectively). As a conclusion, buah merah could decrease the level of parasitemia, as well as TNF-a and ICAM-1 serum levels in Plasmodium berghei-inoculated mice.Keywords: red fruit, Pandanus conoideus Lam., TNF-a, Parasitemia, ICAM-1, Plasmodium berghei