Combination Therapy Model of Cempedak Stembark Ethanol 80% Extract (Artocarpus champeden Spreng.) and Artesunat on Malaria Parasite Infected Mice
| Main Authors: | Hafid, Achmad Fuad; Faculty of Pharmacy, Airlangga University, Surabaya, Tyas, Maharani Wahyuning; Faculty of Pharmacy, Airlangga University, Surabaya, Widyawaruyanti, Aty; Faculty of Pharmacy, Airlangga University, Surabaya |
|---|---|
| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2011
|
| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/356 |
Daftar Isi:
- Parasite resistance to antimalarial become a major problem in health. Combination therapy with artemisinine derivates or known with term ACT (Artemisinine-based Combination Therapy) was suggested by WHO as alternative therapy to control the spreading resistance of Plasmodium falciparum. Combination therapy of Cempedak stembark (Artocarpus champeden Spreng.) 80% Ethanolic Extract (ACEE) and Artesunate on Plasmodium berghei infected mice was studied. The study was carried out by oral administration of ACEE and artesunate. Treatment groups were divided in (A) ACEE 100 mg/kg bw daily for three concecutive days; (B) Artesunate 36,4 mg/kg bw daily for three consecutive days; (C) combination of ACEE 100 mg/kg and Artesunate 36,4 mg/kg daily for three concecutive days; (D) combination of ACEE 100 mg/kg daily for three concecutive days and Artesunate 36.4 mg/kg daily at day one; (E) combination of ACEE 100 mg/kg for three concecutive days and Artesunate 36.4 mg/kg daily at day three. The result showed that A, B, C, D, and E inhibit parasite’s growth for 62.6%; 66.8%; 82.3%; 67.8%; 70.2% respectively. It showed that C gives the highest antimalarial activity among all groups. Based on one way Anova, the treatment groups showed statistically significant difference (p=0.00; p<0.05) for inhibiton of parasite growth. The research revealed that combination of ACEE 100 mg/kg and Artesunate 36.4 mg/kg daily for three concecutive days (model C) on P.berghei infected mice is the most potential therapy model.Keywords: Artocarpus champeden extract, combination therapy, Artesunate,inhibition of parasite’s growth.