Blood Lactate Level Validity in Detecting Plasma Leakage in Dengue Virus Infection on Children
| Main Authors: | Santosa, Dicky; Faculty of Medicine Padjadjaran University/ Hasan Sadikin General Hospital, Bandung, Alwi, Enny Harliany; Faculty of Medicine Padjadjaran University/ Hasan Sadikin General Hospital, Bandung, Idjradinata, Ponpon S.; Faculty of Medicine Padjadjaran University/ Hasan Sadikin General Hospital, Bandung |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2011
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/205 |
Daftar Isi:
- Dengue virus infection is a tropical viral disease that attack humans in the world until now. The difference between DHF and DD is the presence of increasing vascular permeability in DHF, which resulted in plasma leakage, blood flow decreased, impaired microcirculation and tissue perfusion, decreased on oxygen and nutrient supply to the organs that cause anaerobic metabolism with lactic acid production. This study determines the validity of blood lactate levels in detecting plasma leakage in dengue virus infection of children. The study was conducted during January-February 2010. The research used cross-sectional study. Subjects were 60 children aged <14 years who came to the Emergency Room and Pediatrics Clinic of Dr. Hasan Sadikin Hospital Bandung. Suspected dengue virus infection was made according to WHO criteria (1997). Blood sampling was performed to examine blood lactate and hematocrit. The optimum value sensitivity and specificity of cut points wasdetermined by receiver operating curve characteristic (ROC). Cut point of blood lactate level,(>2.4 mmol/L) gave a sensitivity 79.31%, specificity 77.42%. This study shows that the value of blood lactate level >2.4 mmol/L can be used as a marker of plasma leakage in dengue virus infection of children.Key words: dengue virus infection, plasma leakage, hemoconcentration, blood lactate levels