Serum Creatinine and Cystatin C Level in Children with Undernutrition and Normal Nutritional Status
| Main Authors: | Kartawinata, Yeliana; Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Hilmanto, Dany; Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Nataprawira, Heda Melinda; Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung |
|---|---|
| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2012
|
| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/1256 |
Daftar Isi:
- Introduction: Undernourished children may suffer renal impairement which shown as a decreaseof glomerular filtration rate (GFR). Measurement of GFR using serum creatinine isinfluenced by muscle mass, hence less acurate compared with cystatin C. The aim of this study was to determine differences of serum creatinine and cystatin C in groups of children with undernutrition and normal nutritional status based on World Health Organization child growth standard (WCGS).Method: This cross-sectional study was conducted from April–August 2012 at Department ofChild Health Hasan Sadikin Hospital, Bandung on 70 children aged 1–5 years. They were divided into undernutrition and normal group. Serum creatinine was examined by Jaffe method and cystatin C was by particle enchanced immunoturbidimetric assay (PETIA). The differences of serum creatinine and cystatin C level between those groups were analyzed by unpaired t test and considered significant if p<0.05.Results: The mean serum creatinine in undernutrition and normal group were 0.25 mg/l [standard deviation (SD)=0.06] and 0.31 mg/l (SD=0.11), respectively with p=0.001. The mean serum cystatin C in undernutrition and normal group were 0.80 mg/l (SD=0.24) and 0.71 mg/l (SD=0.22), respectively with p=0.043.Conclusions: In undernutrition group, serum creatinine level was lower and serum cystatin Clevel was higher than normal group. J Indon Med Assoc. 2012;62:471-4.Keywords: Cystatin C, serum creatinine, undernutrition