Estrogen Receptor b as A Potential Predictive Marker of Malignancy in Atypical Ductal Hyperplasia of The Breast
| Main Authors: | Harahap, Agnes Stephanie; Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo Hospital, Jakarta, Hardjolukito, Endang Sri Roostini; Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo Hospital, Jakarta, Rustamadji, Primariadewi; Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo Hospital, Jakarta, Siregar, Nurjati Chairani; Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo Hospital, Jakarta |
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| Format: | application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Journal of the Indonesian Medical Association
, 2012
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| Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/1254 |
Daftar Isi:
- Introduction: Estrogen receptor a (ER a) and estrogen receptor b (ER b) play a role in breastcancer progression through multistep carcinogenesis. Estrogen receptor b is a tumor supressorand its expression decreases during the tumor progression. Atypical ductal hyperplasia (ADH) is an intraductal proliferative lesion of the breast and has four to five times higher risk to become a carcinoma. The objective of this study is to obtain a marker that can predict malignant potential in ADH through expression of ER b.Methods: This is an analytic cross-sectional study using 24 cases of ADH without carcinoma and 24 cases of ADH with carcinoma. Estrogen receptor b status were assesed by immunohistochemistry and the H score.Results. ER b H score in ADH without carcinoma is significantly higher than ADH with carcinoma (p=0.006). ER b is catagorized as high if the H score >229.2.Conclusion: ER b can be used as a potential malignant predictive marker in ADH. J Indon MedAssoc. 2012;62:462-6.Keywords: Atypical ductal hyperplasia, breast carcinoma, estrogen receptor b