P16INK4A Expression In Cervical Carcinoma Young Age
Main Authors: | Sinuhaji, Immanuel; Faculty of Medicine University of Indonesia/ Cipto Mangunkusumo Hospital, Jakarta, Siregar, Budiningsih; Faculty of Medicine University of Indonesia/ Cipto Mangunkusumo Hospital, Jakarta, Lisnawati, Lisnawati; Faculty of Medicine University of Indonesia/ Cipto Mangunkusumo Hospital, Jakarta |
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Format: | application/pdf eJournal |
Bahasa: | eng |
Terbitan: |
Journal of the Indonesian Medical Association
, 2013
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Online Access: |
http://indonesia.digitaljournals.org/index.php/idnmed/article/view/1246 |
Daftar Isi:
- Introduction. Cervical carcinoma is still the highest prevalent malignancy in Indonesia. Therefore, early identification of the high risk lesion is needed. Antibody p16INK4Ais frequently found in high grade lesion and invasive carcinoma. The aims of study was to compare p16INK4A expression in young and old age, due to increased efficacy of prevention and early identification of invasive lesion.Methods. This cross-sectional study was performed on 30 formalin-fixed parafin embeded specimen of squamous cell carcinoma orginated from patient with young age (<30 years) and old age (45-55 years) respectively. The immunohistochemical staining was conducted againts p16INK4A protein to compare both of group.Results: P16INK4A expression in both group showed a strong result, both in nucleus or cytoplasm. However, there was no statistical difference between the expression of p16INK4A in young age groups and old age (p=0,951).Conclusion: There is no association between p16INK4A expression in young and old age. J Indon Med Assoc. 2013;63:4-8 .Keywords: cervical carcinoma, human papilloma virus, p16INK4A.