Sinergism effect anticancer of etyl acetat fraction calotropis gigantea roots (eacgr) with 5 fluorouracil on human breast cancer T47D cell lines
| Main Author: | Mutiah, Roihatul |
|---|---|
| Format: | Proceeding PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
, 2017
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| Subjects: | |
| Online Access: |
http://repository.uin-malang.ac.id/1993/2/1993.pdf http://repository.uin-malang.ac.id/1993/ http://greentech.uin-malang.ac.id |
Daftar Isi:
- Objective: The objective of this study was to know the synergism effect of etyl acetat fraction Calotropis gigantea roots (EACGR) with 5 fluorouracil on human breast cancer t47d cell lines. Methods: MTT assay was used to measure the growth inhibitory effect of the combination. Results: The data analysis showed that combination therapy of EACGR and 5 Fluorouracil have been synergistic effect at7 μg/ml EACGR and 32.5 μg/ml 5-FU, with Combination Index value (CI) ranging from 0.20 to 0.07. The effect minor synergistic of this combination was showed at dose 7 μg/ml EACGR and 62.5 μg/ml 5-FU, with Combination Index value (CI) ranging from 0.7 to 0.9. Conclusion: Combination therapy of 7 μg/ml EACGR and 32.5 μg/ml 5-FU have been synergistic anticancer effect on human breast cancer cell line T47D.