Effect of L-arginine on improvement of alveoli capillary wall thickness
| Main Authors: | Sulistyowati, Sri, Avisena, Yasir, R, Supriyadi Hari |
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| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University
, 2018
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| Subjects: | |
| Online Access: |
http://e-journal.unair.ac.id/MOG/article/view/7963 http://e-journal.unair.ac.id/MOG/article/view/7963/4702 |
Daftar Isi:
- Objectives: This study aims to demonstrate the effect of L-Arginine on pulmonary edema on mice preeclampsia model.Materials and Methods: This experimental analytic study was conducted on 30 pregnant mice divided into 3 groups, namely 10 normal pregnant mice (K1), 10 pregnant mice preeclampsia model (K2), and 10 pregnant mice pre-eclampsia model who received L-Arginine (K3) therapy. All subjects examined the thickness of the alveoli capillary wall in their pulmo using the Immunohisto-chemical method. The results were analyzed using Kruskal Wallis and Mann Whiteney tests.Results: Average alveoli capillary wall thickness (K1) 5.01±1.76/μm, (K2) 11.57±7.11/μm, with p value=0.00. Average alveoli capillary wall thickness (K3) 7.90±4.10/μm with p value=0.01.Conclusion: L-arginine affects to improve pulmonary edema in preeclampsia by reducing alveoli capillary wall thickness of the pulmonary in mice model.