The difference of PGE2 and COX-2 expressions in various histological grading of endometrial endometrioid carcinoma
| Main Authors: | Rosdiana, Yusfita Evi, Sandhika, Willy |
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| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University
, 2018
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| Subjects: | |
| Online Access: |
http://e-journal.unair.ac.id/MOG/article/view/7947 http://e-journal.unair.ac.id/MOG/article/view/7947/4690 |
Daftar Isi:
- Objectives: to analyze the expression of PGE2 and COX-2 in various histological grade of endometrial endometrioid carcinoma.Materials and Methods: Analytical observational study was performed on parafin block archives of endometrial endometrioid carcinoma with histological grade 1,2 and 3 in Anatomic Pathology laboratory Dr. Soetomo hospital. PGE2 and COX-2 expression were examined by immunohistochemical staining using PGE2 and COX-2 antibodies. The results were analyzed statistically.Results: There were increase of PGE2 expressions of in endometrioid carcinoma grade 2 compare to grade 1 and grade 3 compare to grade 2. The COX-2 expression was increase in histologic grade 3 compare to grade 1.Conclusion: The expression of PGE2 and COX-2 in endometrial endometrioid carcinoma were increased in higher histologic grade compare to lower histologic grade.