Isolation and Protection Effects of Methyl Gallate from Surian Leaves (Toona sureni BL Merr) Against Atherosclerosis of Hypercholesterolemic Rat
| Main Authors: | Suhatri, Suhatri, Yanwirasti, Yanwirasti, Nasrul, Ellyza , Dachriyanus, Dachriyanus, Indrawan, Satriko, Marusin, Netty , TOBAT, SANUBARI RELA , Yuliandra , Yori |
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| Format: | Article NonPeerReviewed application/pdf |
| Terbitan: |
RJPBCS
, 2016
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| Subjects: | |
| Online Access: |
http://repository.unand.ac.id/23768/1/rjpbcs%20vol%207%20no%204%202016%20final.pdf http://rjpbcs.com http://repository.unand.ac.id/23768/ |
Daftar Isi:
- A study on the protection effect of methyl gallate (MG) isolated from Toona sureni leaves against atherosclerosis has been carried out. Mice with high blood cholesterol level were obtained by feeding with high fat diet and inducing propyl thiouracil (PTU). Methyl gallate was administered orally at the doses of 5, 10, and 20 mg/kg. Histopathologic examination was conducted to measure the aortic wall thickness (AWT) and to observe any improvement of endothelial layer. The study showed that MG at doses of 5 and 10 mg/kg exhibited protection against the atherosclerosis indicated by its ability to prevent the thickening of aortic wall and damage of endothelial layer. This study concludes that methyl gallate isolated from Toona sureni leaves exhibits a protective effect against atherosclerosis in hypercholesterolemic mice.