J.Natural Product Communications,2017,12(11):Chemical Constituents of Aglaia odorata Leaves and Their Anti-inflammatory Effects
| Main Author: | Efdi, Mai |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Sage Publications
, 2017
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| Subjects: | |
| Online Access: |
http://repo.unand.ac.id/43742/1/NPC%202017.pdf http://repo.unand.ac.id/43742/2/NPC%202017.pdf http://repo.unand.ac.id/43742/ https://journals.sagepub.com/toc/npxa/12/11 |
Daftar Isi:
- Aglaia odorata Lour. is a traditional herbal medicine belonging to the Meliaceae family. The aim of this study was to identify useful compounds for human health from A. odorata. Our phytochemical investigation resulted in the isolation of four constituents hesperetin-7,3'-O-dimethylether, 5α-dammar-20-ene�3,24,25-triol, odorine, and odorinol. All compounds suppressed LPS-induced TNF- expression in rat immortalized microglia HAPI cells; especially, hesperetin-7,3'-O-dimethylether showed most potent inhibitory effect. In addition, molecular docking analysis demonstrated that hesperetin-7,3'-O�dimethylether could be accommodated within hot spots of TNF- dimeric protein