Identifikasi Mekanisme Molekuler Senyawa Bioaktif Peptida Laut sebagai Kandidat Inhibitor Angiotensin-I Converting Enzyme (ACE)
| Main Authors: | Fakih, Taufik Muhammad, Dewi, Mentari Luthfika |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | ind |
| Terbitan: |
Universitas Andalas
, 2020
|
| Subjects: | |
| Online Access: |
http://repo.unand.ac.id/36701/1/598-2203-5-PB.pdf http://repo.unand.ac.id/36701/ http://doi.org/10.25077/jsfk.7.1.76-82.2020 |
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36701 |
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<dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><relation>http://repo.unand.ac.id/36701/</relation><title>Identifikasi Mekanisme Molekuler Senyawa Bioaktif Peptida Laut sebagai Kandidat Inhibitor Angiotensin-I Converting Enzyme (ACE)</title><creator>Fakih, Taufik Muhammad</creator><creator>Dewi, Mentari Luthfika</creator><subject>RS Pharmacy and materia medica</subject><description>Marine peptide bioactive compounds are currently the focus of research because they have unique properties. One important biological roles of these peptide compounds is an antihypertensive agent against Angiotensin-I Converting Enzyme (ACE) activity. There are several peptide compounds that have been proved to inhibit ACE receptors, such as peptide compounds produced by sea cucumbers (Acaudina molpadioides), blue shellfish (Mytilus edulis), and tuna fish (Thunnini). In this research, identification and evaluation of interactions that occur between peptide compounds with ACE receptors were carried out using protein-peptide docking methods. Sequencing of peptide compounds was modeled using PEP-FOLD server. The best conformation was chosen to explore the interaction of ACE receptor macromolecules using PatchDock software. Interactions that occur were
observed further using BIOVIA Discovery Studio 2020 software. Based on the results of protein-peptide docking, blue shellfish peptide compounds and tuna fish had a good affinity for the ACE receptor, in which the ACE score were −391.62 kJ/mol and −516.56 kJ/mol, respectively. Thus, the marine peptide bioactive compound is predicted to be a promising candidate for peptidebased ACE receptor inhibitors.</description><publisher>Universitas Andalas</publisher><date>2020-04-30</date><type>Journal:Article</type><type>PeerReview:PeerReviewed</type><type>Book:Book</type><language>ind</language><rights>cc_by_sa_4</rights><identifier>http://repo.unand.ac.id/36701/1/598-2203-5-PB.pdf</identifier><identifier> Fakih, Taufik Muhammad and Dewi, Mentari Luthfika (2020) Identifikasi Mekanisme Molekuler Senyawa Bioaktif Peptida Laut sebagai Kandidat Inhibitor Angiotensin-I Converting Enzyme (ACE). Jurnal Sains Farmasi & Klinis, 7 (1). pp. 76-82. ISSN 2407-7062 </identifier><relation>http://doi.org/10.25077/jsfk.7.1.76-82.2020</relation><relation>doi:10.25077/jsfk.7.1.76-82.2020</relation><recordID>36701</recordID></dc>
|
| language |
ind |
| format |
Journal:Article Journal PeerReview:PeerReviewed PeerReview Book:Book Book |
| author |
Fakih, Taufik Muhammad Dewi, Mentari Luthfika |
| title |
Identifikasi Mekanisme Molekuler Senyawa Bioaktif Peptida Laut sebagai Kandidat Inhibitor Angiotensin-I Converting Enzyme (ACE) |
| publisher |
Universitas Andalas |
| publishDate |
2020 |
| topic |
RS Pharmacy and materia medica |
| url |
http://repo.unand.ac.id/36701/1/598-2203-5-PB.pdf http://repo.unand.ac.id/36701/ http://doi.org/10.25077/jsfk.7.1.76-82.2020 |
| contents |
Marine peptide bioactive compounds are currently the focus of research because they have unique properties. One important biological roles of these peptide compounds is an antihypertensive agent against Angiotensin-I Converting Enzyme (ACE) activity. There are several peptide compounds that have been proved to inhibit ACE receptors, such as peptide compounds produced by sea cucumbers (Acaudina molpadioides), blue shellfish (Mytilus edulis), and tuna fish (Thunnini). In this research, identification and evaluation of interactions that occur between peptide compounds with ACE receptors were carried out using protein-peptide docking methods. Sequencing of peptide compounds was modeled using PEP-FOLD server. The best conformation was chosen to explore the interaction of ACE receptor macromolecules using PatchDock software. Interactions that occur were
observed further using BIOVIA Discovery Studio 2020 software. Based on the results of protein-peptide docking, blue shellfish peptide compounds and tuna fish had a good affinity for the ACE receptor, in which the ACE score were −391.62 kJ/mol and −516.56 kJ/mol, respectively. Thus, the marine peptide bioactive compound is predicted to be a promising candidate for peptidebased ACE receptor inhibitors. |
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