Peningkatan kelarutan Kuersetin Melalui pembentukan Kompeks Inklusi dengan β-Siklodekstrin
| Main Authors: | Syofyan, Syofyan, Henny, Lucida, Amri, Bakhtiar |
|---|---|
| Format: | Article PeerReviewed Book Lainnya |
| Bahasa: | eng |
| Terbitan: |
Fakultas Farmasi
, 2008
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| Subjects: | |
| Online Access: |
http://repo.unand.ac.id/2734/1/Jurnal_04.pdf http://repo.unand.ac.id/2734/2/Jurnal_04.ps http://repo.unand.ac.id/2734/ |
Daftar Isi:
- Quercetin, a chemical cousin of the glycoside rutin from Manihot esculenta Crantz, appears to have several biologically activities. Preformulation studies usually associated with a new potent drug substances, includes solubility. The complexation of quercetin by β-Siklodekstrin indicated an A-type diagram with inclusion complex of 1:1 molar ratio and the stability constant (K) of 403,58 M-1. the complexation enhance solubility 9-fold compared with that of quercetin, howers it was not effective for liquid and oral pharmaceutical applications. Keyword: Quercetin, β-Siklodekstrin, complex of inclusion, solubility