EFEK FETOTOKSISITAS EKSTRAK BIJI MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.)PADA MENCIT
| Main Authors: | Almahdy, A, Rika, Febrianti, Rusjdi, Djamal |
|---|---|
| Format: | Monograph NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Farmasi
, 2009
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| Subjects: | |
| Online Access: |
http://repo.unand.ac.id/1802/1/almahdy_-_mdewa_in_vivo.doc http://repo.unand.ac.id/1802/ |
Daftar Isi:
- In order to evaluate Phaleria macrocarpa (Scheff.) Boerl. (Mahkota Dewa) seed extract for possible embryo-fetotoxicity effects and disturbance of postnatal development of pups, female mice were treated on days 6-14 of pregnancy with either the extract (50, 100 and 200 mg/BW) or distilled water (1 ml/mouse), by gastric intubation. Half of the fetus was fixated in red alizarin for skeletal observation and the other half was soaked in Bouin solution. Fetals study suggest of embryo-fetotoxicity on the pups indicating that the seed may be not safe for mice on two higher doses 100 and 200 mg/kg BW. Keywords : fetotoxicity, Phaleria macrocarpa, mice