Formulasi Tablet Klorfeniramin Maleat Menggunakan Selulosa Mikrokristal dengan Metode Cetak Langsung
| Main Author: | Sihaloho, Jandri Duvico |
|---|---|
| Other Authors: | Ramlan, Kasmirul, Karsono |
| Format: | Student Papers |
| Bahasa: | ind |
| Subjects: | |
| Online Access: |
http://repository.usu.ac.id/handle/123456789/25801 |
Daftar Isi:
- Microcrystalline cellulose is an exipient which often used in the manufacture of tablets by direct compression. The purpose of this research is to apply the use of microcrystalline cellulose isolated from nata de coco as a diluent in the manufacture of chlorpheniramin maleate tablets by direct compression. Microcrystalline cellulose obtained by isolation from nata de coco. Isolation was carried out by extraction using 18% sodium hydroxide to produce α-cellulose and α-cellulose is hydrolyzed using hydrochloric acid 2.5 N to produce microcrystalline cellulose. Microcrystalline cellulose obtained from nata de coco (SMNDC) was characterized include pH, loss on drying, density and compressibility index. In addition, analysis of physicochemical properties of SMNDC used infrared spectrophotometer instruments. There are two formula tablets. Formula 1(F1) is with SMNDC as diluent and formula 2 (F2) is with Avicel PH 102 as a comparison. Furthermore, the tablets evaluated include weight uniformity, tablet hardness, friability, disintegration time, quantitative analysis of active agent test, and dissolution test. The results of characterization that is pH of SMNDC and avicel PH 102 was 5.8 and 6.5; loss on drying of SMNDC and avicel was 4.75% and 7.54%; bulk density of SMNDC and avicel is 0.583 g/cm3 0.416 g/cm3;true density of SMNDC and avicel was 1.450 g/cm3 and 1.460 g/cm3; compressibility index of SMNDC and avicel was 18.181% and 15.860 g/cm3. The results of evaluation chlorpheniramine maleate tablets include hardness of F1dan F2 was 4.65 kg and 5.90 kg; disintegration time of F1 and F2 was 4.32 and 4.13 minutes; the determination of active agent of F1 and F2 was 100.47 ± 5, 07 and 102.32 ± 5.49 and dissolution test results of F2 and F1 showed that the cumulative amount of active agent released in the 30th minute was 100.2% and 99.53%.The results showed that the two tablet formula meets the requirements contained in the pharmacopoeia of Indonesia and the United States Pharmacopeia. However, the friability test doesnt fulfill the literature terms.
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