Peranan Kadar Feritin Dan Asam Urat Serum Sebagai Faktor Prognostik Pada Stroke Iskemik Akut
| Main Author: | Fitri, Fasihan Irfani |
|---|---|
| Other Authors: | Sjahrir, Hasan |
| Format: | Masters |
| Bahasa: | ind |
| Subjects: | |
| Online Access: |
http://repository.usu.ac.id/handle/123456789/25566 |
Daftar Isi:
- Background and Purpose : Ischemic stroke remains a major healthcare problem and a leading cause of mortality and disability. Experimental studies provide evidence of an association between ischemic stroke and increased oxidative stress. Iron overload, as measured by high serum ferritin levels, has been associated with greater oxidative stress, whereas uric acid has been shown to have an antioxidant capacity. The purpose of this study was to investigate the role of serum ferritin and uric acid as prognostic factors of ischemic stroke outcome. Methods : This was an observational cross-sectional study performed on acute ischemic stroke patients in Adam Malik General Hospital in August 2009 until May 2010. Acute ischemic stroke diagnosis was established based on history, neurological examination and cranial CT that were performed on admission. Serum ferritin and uric acid were measured within 24-48 hours from admission. Stroke outcome was` evaluated by using the National Institute of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Barthel Index (BI) on fourteenth day. Results : Thirty three patients, consisted of 18 men and 15 women were studied. There was no significant difference on ferritin and uric acid levels based on age, sex and stroke risk factors. There was a significant positive correlation between serum ferritin and uric acid (r=0,345,p=0,049). A stepwise multiple regression revealed that higher ferritin and lower uric acid levels independently predicted higher NIHSS and mRS scores, and lower BI score, while lower ferritin and higher uric acid levels independently predicted lower NIHSS and mRS scores and higher BI score. Conclusions : Serum ferritin and uric acid have a role as prognostic factors for outcome in ischemic stroke patients. Higher serum ferritin and lower uric acid were prognostic factors for poor outcome in ischemic stroke patients. This finding may reinforce the relevance of oxidative damage in ischemic stroke.
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