Studi Molekuler pada Instabilitas Genetik Mekanisme Kerusakan DNA dan Proses Perbaikannya
| Main Authors: | Corvianindya, Yani; Department of Oral Biology, Faculty of Dentistry, Universitas Jember, Auerkari, Elza Ibrahim; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Dentistry, University of Indonesia
, 2015
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| Online Access: |
http://www.jdentistry.ui.ac.id/index.php/JDI/article/view/936 http://www.jdentistry.ui.ac.id/index.php/JDI/article/view/936/837 |
Daftar Isi:
- The life survival of individuals depends on their DNA stability. Radiation exposure, physical and chemical change, and also replication errors can induce DNA lesions. Multiple pathways are involved in the maintenance of genetic integrity, most link to the cell cycle. By arresting the cell cycle, checkpoints allow cells to repair DNA when damage to the genome is detected. Genes induced in genetic instability to respond to DNA damage include ATM, p53, p21, BRCA1 and Chk2. Cells have various DNA repair systems to keep homeostasis condition with enzymes that search for some changes or distortion to be repaired.