Dentinogenesis Imperfekta Aspek Genetika Molekular, Klasifikasi dan Upaya Penanggulangannya
| Main Authors: | Auerkari, Elza Ibrahim; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Surjadi, A.; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Mangoendjaja, S.; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430 |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Dentistry, University of Indonesia
, 2015
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| Online Access: |
http://www.jdentistry.ui.ac.id/index.php/JDI/article/view/814 http://www.jdentistry.ui.ac.id/index.php/JDI/article/view/814/717 |
Daftar Isi:
- Dentinogenesis Imperfecta (DI) is a hereditary simple autosomal dominant disorder showing abnormalities in the dentin of developing teeth and occuring at a rate of about 1 in 8000 births affecting both primary and secondary dentitions. The expression of DI shows a high penetrance and a low mutation rate. Two main types of DI appear to exist: type 1 which is the defect associate with osteogenesis imperfecta, and type II which is the classical hereditary opalescent dentin. The formerly proposed DI type III appears to be only a modified expression of the same gene as in the classical DI type II. This paper reviews molecular genetic aspects of DI.