The Effect of Different Intensities of Treadmill Exercise on FGF23 Gene Expression in Gastrocnemius and Soleus Muscles of Wistar Rats
| Main Authors: | Gunadi, Julia Windi, Jasaputra, Diana Krisanti, Gunawan, Decky, Edwinanto, Ludovicus, Kwee, Limdawati, Pramono, Harijadi, Suhendra, Adrian, Sariwidyantry, Ghita, Goenawan, Hanna, Lesmana, Ronny |
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| Format: | Proceeding PeerReviewed Book |
| Terbitan: |
, 2021
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| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/31841/1/The%20Effect%20%281%29.pdf http://repository.maranatha.edu/31841/ |
Daftar Isi:
- Fibroblast growth factor 23 (FGF23) acts as a hormone that regulates phosphate metabolism associated with kidney function, and an inducer of left ventricle hypertrophy. But the role of FGF23 as a myokine has not yet to be confirmed. This research aims to investigate the effect of different intensities of treadmill exercise on FGF23 gene expression in gastrocnemius and soleus muscles of Wistar rats. Twenty male Wistar rats were given different intensities of treadmill exercise (low, moderate, and high) for as long as 8 weeks. FGF23 gene expression in gastrocnemius and soleus muscles was examined using semi-quantitative PCR. In this study, we obtained no change of relative FGF23 mRNA expression in gastrocnemius muscles (p = 0.684) compared to control. But interestingly, we found a significant increase of relative FGF23 mRNA expression in soleus muscles (p = 0.030). These results showed that different intensities of treadmill exercise do not stimulate FGF23 gene expression in gastrocnemius muscles of Wistar rats. While the low intensity of treadmill exercise does not increase FGF23 relative mRNA expression, moderate and high intensities of treadmill exercise increase FGF23 gene expression in the Wistar rat’s soleus muscles.