P0192 The Concentration of Soluble Mica as Prognostic Factor in Nasopharyngeal Carcinoma
| Main Authors: | Ratnawati, Hana, Mubarika, S., Astuti, I. , Hariwianto, B., Retnoningrum, D. |
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| Format: | Article PeerReviewed Book |
| Terbitan: |
, 2014
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| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/30224/1/Journal%20International_NPC.pdf http://repository.maranatha.edu/30224/ |
Daftar Isi:
- In Indonesia, nasopharyngeal carcinoma (NPC), a malignancy of the head and neck, has a high mortality rate because patients are usually diagnosed at an advance stage and, in some, metastasis has even occured. When diagnosed at an early stage, 5-year survival rates can reach more than 80%, but at advance stages, 5-year survival rate is only 10–40%. Epstein-Barr virus is associated with the pathogenesis of NPC. These viral-induced carcinoma express the stress surface protein molecules MHC class I-related chain A (MICA), part of an important activation pathway to trigger the immune system to attack tumour cells. However, the virus and cancer cells might downregulate the expression of membrane-bound MICA (mMICA) molecules and increase the soluble MICA (sMICA) concentration, therefore reducing the immunogenicity of the tumour cell and decreasing the prognosis. We aimed to determine the concentration of sMICA as prognostic factor in NPC.