Non-Viral Risk Factors of Nasopharyngeal Carcinoma in Sumedang Municipal Hospital, Indonesia
| Main Authors: | Daud, Fari Ananda, Ratnawati, Hana |
|---|---|
| Format: | Proceeding PeerReviewed Book |
| Terbitan: |
, 2015
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| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/30220/1/International%20Symposium%20on%20nasopharyngeal%20carcinoma.pdf http://repository.maranatha.edu/30220/ |
Daftar Isi:
- Nasopharyngeal carcinoma is a disease with a remarkable racial and geographical distribution. In Sumedang Municipal Hospital as well as in Indonesia, nasopharyngeal carcinoma is the first malignancy of the head and neck with a high mortality rate. Chronic infection by Epstein-Barr Virus (EBV), environmental factors and genetic factors play an important role in the pathogenesis of nasopharyngeal carcinoma. EBV genome was found in almost all cases of nasopharyngeal carcinoma and encode viral proteins that contribute to the development of malignancy, especially in undifferentiated nasopharyngeal carcinoma the association close to 100%, but no data about the role of the genetic susceptibility and environmental factors, such as dietary factors, smoking and solvent exposure in the pathogenesis of nasopharyngeal carcinoma. The aim of this study is to describe the frequency of genetic susceptibility and environmental non-viral factors in nasopharyngeal cancer patiens in Sumedang Municipal Hospital. This research design was an observational descriptive study using a questionnaire to all patients with nasopharyngeal carcinoma at Sumedang Municipal Hospital in 2014. The subjects were all the nasopharyngeal carcinoma patients in Ear, Nose and Throat policlinic, which already diagnosed by histopathological biopsy. The results showed that the average age is 45.8 years with the ratio between women : men is 1 : 2.2. The 3 main risk factors in patients with nasopharyngeal carcinoma were, consumption of salted fish more than 3 times per month (75%), smoking more than 10 cigarettes per day (65%) and frequent exposure to wood burning smoke (55%).