Anti-inflammatory andantiaging properties ofchlorogenicacidon UV-induced fibroblast cell
| Main Authors: | Girsang, Ermi, Ginting, Chrismis N. , Lister, I Nyoman Ehrich, Gunawan, Kamila Yashfa, Widowati, Wahyu |
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| Format: | Article PeerReviewed Book |
| Terbitan: |
, 2021
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| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/27819/3/61.Int%20Publikasi%202021-4%20%28Wahyu%20PeerJ-Wahyu%20FKUKM%29%20Reviewer.pdf http://repository.maranatha.edu/27819/1/Anti-inflammatory%20and%20antiaging%20properties%20of%20chlorogenic%20acid%20on%20UV-induced%20fibroblast%20cell.pdf http://repository.maranatha.edu/27819/ |
Daftar Isi:
- Background: Skin agingisthemostcommondermatologicalproblemcausedby intrinsic andextrinsicfactor,suchasexposureto(ultraviolet)UVrays.Chlorogenic acid (CA)isaphenoliccompoundwhichisknownforitsantioxidantproperties against oxidativestress. Objective: This studyinvestigatestheantiagingandanti-inflammatory propertiesof CA onUV-inducedskin fibroblast cells. Methods: Anti-inflammatory propertiesofCAwereassessedbymeasuring inflammatory-relatedproteinsIL-1β and TNF-a, whileantiagingpropertiesofCA were assessedbymeasuringreactiveoxygenspecies(ROS),apoptosis,liveand necrotic cells,andCOL-3geneexpressionlevel. Results: Treating UV-inducedskin fibroblast cellswithCAdecreasedthelevelof ROS, IL-1β, TNF-a, apoptoticcells,andnecroticcellsandincreasedlivecellsand COL-3 geneexpression. Conclusion: CA hasthepotentialastheprotectivecompoundagainstinflammation and agingbydecreasingthelevelROS,pro-inflammatory cytokinesIL-1β and TNF-a, apoptoticcells,andnecroticcellsandbyincreasinglivecellsandCOL-3gene expression.