Oral Mucosa Wound Healing Activities of Aloe vera Extract: in Vivo Study
| Main Authors: | Sugiaman, Vinna K. , Pranata, Natallia, Kintawati, Silvi, Maskoen, Ani M., Rezano, Andri |
|---|---|
| Format: | Article PeerReviewed Book |
| Terbitan: |
, 2018
|
| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/27057/1/Oral%20Mucosa%20Wound%20Healing%20Activities.pdf http://repository.maranatha.edu/27057/ |
Daftar Isi:
- Aloe vera L. (Liliaceae) in culture has been used for herbal medicine is also known as the healing plant. Wound healing property of Aloe vera on the skin has been proven. In contrast, the healing of oral mucosa is slightly different from the skin. Fibroblast in oral mucosa phenotypically resemble fetal fibroblast. This study will analyze the effect of Aloe vera on the healing process of wound in oral mucosa of 24 male Wistar rat. Expression of transforming growth factor (TGF) β1 and inflammation effect was analyzed by immunohistochemistry (IHC) and hematoxylin-eosin (HE) staining. Purified (100% concentration) whole leaf extract of Aloe vera was topically applied twice daily, with dose 5 μg/g bw. Result: TGF β1 expression was significantly increased 20-30% at the third (P=0.041) and sixth day (P=0.015). There is no significant reduction of inflammatory cell either on the third (P=0.699) or sixth day (P=1.0). This study shows that Aloe vera enhanced oral mucosa wound healing by TGF β1 marker. There is no significant reduction of inflammatory cell.