The Comparison of Effect between Water and Ethanol Extract of Meniran Herb on the Amount of Eosinophil Percentage in Atopic Dermatitis Mice Model
| Main Authors: | Jasaputra, Diana Krisanti, Santosa, Slamet, Sujatno, Muchtan, Dylan, Rhenata |
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| Format: | Article PeerReviewed Book |
| Terbitan: |
Perhimpunan Dokter Herbal Medik Indonesia
, 2010
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| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/24343/1/2%20JMP%20April%202010%20dr.%20Diana%202.pdf http://repository.maranatha.edu/24343/ |
Daftar Isi:
- Introduction: Atopic dermatitis is hypersensitivity reaction type I which isfollowed by the increasing of eosinophil, which has role in pathogenesis chronic allergic inflammation. One of the treatment target of atopic dermatitis is to decrease the amount of eosinophil, so the inflammation reaction decreased. Meniran herb is usually used by community to treat dermatitis. The aim of this research is tofind out the effect of water and ethanol extract of meniran herb (Phyllanthus niruri. L) to the amount of eosinophil percentage. Methods: The experimental preclinic research in laboratorium is longitudinal, prospective, and comparatives. The mice that induced allergy with ovalbumin were divided randomly in groups (n=6). Various doses of water and ethanol extract meniran herb were given to those groups, then compared to the group which is given the ovalbumin only (controlpositive). The experimental data of the amount of eosinophil percentage was analyzed by ANO VA, whichfollowed by the Duncan test, with a=0,05. Results: the researchproved that decreasing of the amount of eosinophilpercentage doses 1, 2, 3, 4, water meniran extract consecutively 34.833%, 16.167%, 22.833%, 27.833% whereas doses 1, 2, 3, 4, etanol meniran extract consecutively 31.167%, 21.667%,35.167%, 25.833% compared with the positive control (46.833%) (p<0,05). Water and ethanol extract have the same maximum ejfectivity at dose 2 (p>0,05). Conclusion: meniran herb water and ethanol extract have same effect in decreasing the amount of eosinophil percentage.