Inflammation, Immunity, and Cancer: The Role of Transcription Factors NF-kB and STAT3
| Main Authors: | Khie Khiong, -, Adhika, Oeij Anindita, Chakravitha, Melisa |
|---|---|
| Format: | Article PeerReviewed Book |
| Terbitan: |
, 2010
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| Subjects: | |
| Online Access: |
http://repository.maranatha.edu/13201/1/1%20MKI%20OAA.pdf http://repository.maranatha.edu/13201/ |
Daftar Isi:
- A link between inflammation and cancer has long been suspected. Recent studies have identified the role of transcription factors nuclear factor-kB (NF-kB) and signal transducer and activator of transcription 3 (STAT3) in inflammation-induced tumor. In this review, we focus on the role of NF-kB and STAT3 in regulating functions of cancer cells and surrounding non-tumorigenic cells to create a tumor microenvironment that enhance tumor promotion and progression.