Anti-Hyperlipidemic Effect of 70% Ethanol Extract from Mesona palustris Blume Leaves on Male Hamsters
| Main Authors: | Dwitiyanti, Dwitiyanti, Ni Putu Ermi Hikmawati, Ermi, Kriana, Efendi, Riana Puspa Dewi, Riana, Fernita Afriyani, Fernita |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018)
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| Subjects: | |
| Online Access: |
http://repository.uhamka.ac.id/751/1/MICH-PhD_2018_11.pdf http://repository.uhamka.ac.id/751/ |
Daftar Isi:
- In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has been used for various health condition. This study aims to determine the effectiveness of 70% ethanol extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves were extracted using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4 hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose variations (780, 1560, and 3120 mg/Kg body weight each day). All groups except normal control group were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol, LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70% ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was able to decrease blood total cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded that the 70% ethanol extract from black cincau leaves is effective as an anti-hyperlipidemic agent in hyperlipidemic hamster equivalent to positive control group.