Microwave Assisted Synthesis of p-Methoxycinnamamides and p-Methoxy--nitrostyrenes from Ethyl p-methoxycinnamate and Screening their Anti-inflammatory Activity
| Main Author: | Supandi Supandi, Supandi |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Natural Product Communications
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| Subjects: | |
| Online Access: |
http://repository.uhamka.ac.id/577/1/NPC-.pdf http://repository.uhamka.ac.id/577/ |
Daftar Isi:
- A new modification reaction of ethyl p-methoxycinnamate (1) to afford a series of p-methoxycinnamamide and p-methoxy--nitrostyrene has been developed by using the assistance of the unmodified microwave oven. The synthesized compounds were characterized by using various spectroscopic techniques and furthermore screened for their anti-inflammatory activity by using anti-denaturation of heat bovine serum albumin (BSA) method. The result of bioassay indicated that p-methoxycinnamamide derivatives and p-methoxy--nitrostyrenes showed interesting anti-inflammatory activity.