Potency Syzygium cumini L as Adjuvant Therapy on Mice Model Malaria
| Main Authors: | Lilik Maslachah, Rahmi Sugihartuti |
|---|---|
| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
University of Mosul
, 2018
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/98394/3/Bukti%20C%2008%20Potency%20Syzygium%20cumini%20L%20as%20Adjuvant%20....pdf http://repository.unair.ac.id/98394/2/Peer%20review%20C%2008%20Potency%20Syzygium%20cumini%20L%20as%20Adjuvant%20....pdf http://repository.unair.ac.id/98394/1/Bukti%20C%2008%20Potency%20Syzygium%20cumini%20Las%20Adjuvant%20....pdf http://repository.unair.ac.id/98394/ https://vetmedmosul.com/pdf_153801_25cdaac12a973423f0cbaf5f46e61046.html |
Daftar Isi:
- The objective of study was to prove the potential extract of Syzygium cumini L leaf and steam bark as an adjuvant to malaria modelling mice. Antimalarial effects were assessed by the percentage of parasitemia, growth inhibition 50% dose level (ED50), Parasite Clearance Time (PCT), Recrudescence Time (RT) of Plasmodium berghei. Male albino Swiss mice infected with 1x105 P. beghei Parasite in 0.2 ml intraperitoneally. Treatment with chloroquine 25 mg/kg body weight. chloroquine combination 25 mg/kg body weight with leaf and stem bark extract of Syzygium cumini L dose 600 mg/kg body weight for 4 days and 24 hour after infection, and the is activity as antimalarial and adjuvant therapy were observed. The results showed that the extract of Syzygium cumini L leaf combined with chloroquine gives highly significant result in inhibiting the growth of parasites than thw chloeoquine alone and the extract of Syzzygium cumini L leaf combined with chloroquine gives the Parasite Clearance Time faster and Recrudescence Time (RT) longer than the othher treatment Keywords: Syzygium, Plasmodium, Adjuvant