Patofisiologi Iskemik Stroke Terkini (Patophysiology Update of Ischemic Stroke)
| Main Author: | Paulus Sugianto |
|---|---|
| Other Authors: | M. Hasan Machfoed, Hendro Susilo, Isti Suharjanti, Pagan Pambudi |
| Format: | BookSection PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Airlangga University Press
, 2010
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/98162/1/Patofisiologi%20Iskemik_compressed.pdf http://repository.unair.ac.id/98162/2/Patofisiologis%20Iskemik%20Stroke%20Terkini.pdf http://repository.unair.ac.id/98162/ |
Daftar Isi:
- Stroke is a leading cause of disability and health worldwide. Recent data shows that ischaemic stroke is constituting around 80% of all strokes. A better management of stroke can be achieved only if the pathophysiology is properly understood. common conditions associated with ischaemic stroke are trombosis, atherisclerotic proccess, emboli and reducing blood pressure. Appropriate treatment is required as incidence of disability and death are still high. Brain is a small organ with higher consumtion of glucose and oxygen. Failure to provide its need results in permanent damage. This irreversible condition is heralded by depletion of energy metabolites and failure of the cell membrane to maintains its physiologic gradients with dramatic disruption of ion and waterhomeostasis. Atherosclerosis is iniating blood flow disruption, resulting in local reaction and leading to vascular obstruction. This event contributes to inflammatory process, brain oedema, neurond death and penumbra expansion. Understanding of this pathophysiology will reduce incidence of death and disability.