Cytotoxicity of Heterophyllene A, the Derivative of Arylbenzofuran from Stem Bark of Artocarpus calophyl
| Main Authors: | Rumzil Laili, Nanik Siti Aminah, Tin Myo Than, Yoshiaki Takaya, Ainun Sa’adah, Alfinda Novi Kristanti |
|---|---|
| Format: | BookSection PeerReviewed Image Book |
| Bahasa: | eng |
| Terbitan: |
Department Of Chemistry Universitas Sumatera Utara
, 2019
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/98067/1/C29.%20Abstract.pdf http://repository.unair.ac.id/98067/2/C29%20Fulltext_Cytotoxicity%20of_RUMSIL_SCITEPRESS.pdf http://repository.unair.ac.id/98067/3/C29%20Peereviwer1%20Prosiding_Cytotoxicity%20of.pdf http://repository.unair.ac.id/98067/4/C29%20Simialrity%2022%25_Cytotoxicity%20of%20Heterophyllene%20A%2C.....pdf http://repository.unair.ac.id/98067/ |
Daftar Isi:
- Exploration of secondary metabolites was the focus of this research, especially of Artocarpus calophylla species to look for a potential cytotoxic agent. An arylbenzofuran derivative compound, namely heterophyllene A was isolated from the stem bark of Artocarpus calophylla. Structure determination of this compound has been elucidated using UV-Vis spectroscopy, 1D, and 2D NMR analysis. This compound has a lower IC50 than ethyl acetate extract. The IC50 of this compound (57,54 μg/mL) to HeLa and (25,80 μg/mL) to T47D cells, ethyl acetate extract (>100 μg/mL) to HeLa and (84,16 μg/mL) to T47D cells.