Carbazomarin: A New Potential of α-Glucosidase Inhibitor From Clausena excavata Roots
| Main Authors: | Nanik Siti Aminah, Tin M. Thant, Alfinda N. Kristanti, Rico Ramadhan, Hnin T. Aung, Yoshiaki Takaya |
|---|---|
| Format: | Article PeerReviewed Image Book |
| Bahasa: | eng |
| Terbitan: |
Natural Product Communications
, 2020
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| Subjects: | |
| Online Access: |
http://repository.unair.ac.id/97884/1/C01.%20Abstract.pdf http://repository.unair.ac.id/97884/2/C01.%20Fulltext%20-%20CARBAZOMARIN_NPC_TIN_2020.pdf http://repository.unair.ac.id/97884/3/C01.%20Peerreviewer%20-%20Carbazomarin%20A%20New%20Potential%20of.pdf http://repository.unair.ac.id/97884/4/C01.%20Similarity%20-%20CARBAZOMARIN_NPC_TIN_2020%20-%20Copy.pdf http://repository.unair.ac.id/97884/ https://journals.sagepub.com/doi/full/10.1177/1934578X19894076 https://doi.org/10.1177/1934578X19894076 |
Daftar Isi:
- Continuing our exploration for dual functions antidiabetic and antioxidant agents from Myanmar medicinal plant, a new carbazole-pyranocoumarin conjugate, carbazomarin-C (1) along with a known carbazole alkaloid, mukonine (2) and a pyranocoumarin, xanthoxyletin (3), was isolated from the roots of Clausena excavata. The chemical structures of these compounds were identified using a combination of spectroscopic methods. Among isolates, there was a strong inhibition of compounds (1) and (3) on yeast α-glucosidase in a dose-dependent manner. It was shown when p-nitrophenyl-α-d-glucopyranoside was used as a substrate in vitro with IC50 values 0.22 and 4.81 mM, respectively. However, all isolated compounds displayed no inhibition against DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals.